What each one means
SDE (seller's discretionary earnings) is the total financial benefit to a single owner-operator: net profit plus the owner's salary, benefits and personal add-backs. It answers 'what does this business put in the owner's pocket?'
EBITDA (earnings before interest, tax, depreciation and amortisation) measures operating profitability independent of any one owner — it assumes the owner is a paid, replaceable manager.
When each is used
Smaller, owner-run businesses (broadly under about $1M in earnings) are usually valued on SDE, because the owner's role and income are central to the business.
Larger, professionally managed businesses are valued on EBITDA, because they run on a management team rather than a single owner.